Abstract reading meeting

Selected journal : Nature Metabolism Extracellular CD44 lactylation impairs CD8+ T cell function in KRAS-mutant colorectal cancer https://www.nature.com/articles/s42255-026-01482-3 What is the main question of the paper? How do KRAS mutations drive immune evasion in colorectal cancer by regulating TRIP6 phosphorylation, metabolic reprogramming, and the subsequent lactylation of extracellular proteins? How did the anthor address the question? ■Step1 KRAS/ERK-Driven TRIP6 Phosp

Selected journal : Cell metabolism The gut microbiota shapes the human and murine breath volatilome (https://www.cell.com/cell-metabolism/fulltext/S1550-4131(25)00544-3) What is the main question of the paper? Can exhaled volatile organic compound(VOC) profiles reflect the composition and metabolism of the gut microbiota? How did the anthor address the question? ■Step1 Authors showed a correlation between the composition of the gut microbiota and VOCs in exhaled breath in 27

Selected journal : Cell Transplantation of chemically induced pluripotent stem-cell-derived islets under abdominal anterior rectus sheath in a type 1 diabetes patient https://www.cell.com/cell/fulltext/S0092-8674(24)01022-5 What is the main question of the paper? This study investigates whether autologous islets derived from chemically induced pluripotent stem cells (CiPSCs) can safely and effectively restore glycemic control in a patient with type 1 diabetes when transplante

Selected journal : Cell Metabolism Semaglutide ameliorates osteoarthritis progression　through a weight loss-independent metabolic　restoration mechanism Qin et al., 2026, Cell Metabolism 38, 582–597 March 3, 2026 https://doi.org/10.1016/j.cmet.2026.01.008 What is the main question of the paper? How does semaglutide (a GLP-1R agonist) produce chondroprotective effects in metabolic osteoarthritis (OA)? How did the anthor address the question? ■Step1 OA is a degenerative joint