Abstract reading meeting

Selected journal : Cell metabolism Gut microbiota and metabolic control of immune checkpoint blockade in cancer https://www.cell.com/cell-metabolism/fulltext/S1550-4131(26)00156-7 What is the main question of the paper? What are the exact mechanisms by which the gut microbiota and their metabolites control the efficacy of immune checkpoint blockade (ICB) in cancer therapy? How did the anthor address the question? ■Step1 Clinical Correlation: Focused heavily on the detrimental

Selected journal : Science Mechanical load inhibits cancer growth in mouse and human hearts https://www.science.org/doi/epdf/10.1126/science.ads9412 What is the main question of the paper? The main question of this study is to investigate whether the high-intensity mechanical load generated by the continuous beating of the heart serves as a key mechanism for its natural resistance to cancer, including primary tumors and malignant metastases. Also it finds the molecular and ep

Selected journal : Cell Sensory neurons drive immune exclusion by stimulating a dense extracellular matrix in the breast cancer tumor microenvironment https://doi.org/10.1016/j.cell.2026.01.001 What is the main question of the paper? How do sensory neurons interact with the tumor microenvironment? How did the anthor address the question? ■Step1 They demonstrated that in TNBC tumor tissue, sensory neurons accelerate tumor progression by reducing immune cell infiltration and pr

Selected journal : Cell Metabolism Mitochondrial transfer from immune to tumor cells enables lymph node metastasis https://www.cell.com/cell-metabolism/abstract/S1550-4131(25)00545-5?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1550413125005455%3Fshowall%3Dtrue What is the main question of the paper? Why can tumor cells metastasize to and colonize lymph nodes, despite the fact that lymph nodes are rich in immune cells and would therefore seem to be an

Selected journal : Nature Metabolism Extracellular CD44 lactylation impairs CD8+ T cell function in KRAS-mutant colorectal cancer https://www.nature.com/articles/s42255-026-01482-3 What is the main question of the paper? How do KRAS mutations drive immune evasion in colorectal cancer by regulating TRIP6 phosphorylation, metabolic reprogramming, and the subsequent lactylation of extracellular proteins? How did the anthor address the question? ■Step1 KRAS/ERK-Driven TRIP6 Phosp

Selected journal : Cell metabolism The gut microbiota shapes the human and murine breath volatilome (https://www.cell.com/cell-metabolism/fulltext/S1550-4131(25)00544-3) What is the main question of the paper? Can exhaled volatile organic compound(VOC) profiles reflect the composition and metabolism of the gut microbiota? How did the anthor address the question? ■Step1 Authors showed a correlation between the composition of the gut microbiota and VOCs in exhaled breath in 27

Selected journal : Cell Transplantation of chemically induced pluripotent stem-cell-derived islets under abdominal anterior rectus sheath in a type 1 diabetes patient https://www.cell.com/cell/fulltext/S0092-8674(24)01022-5 What is the main question of the paper? This study investigates whether autologous islets derived from chemically induced pluripotent stem cells (CiPSCs) can safely and effectively restore glycemic control in a patient with type 1 diabetes when transplante

Selected journal : Cell Metabolism Semaglutide ameliorates osteoarthritis progression　through a weight loss-independent metabolic　restoration mechanism Qin et al., 2026, Cell Metabolism 38, 582–597 March 3, 2026 https://doi.org/10.1016/j.cmet.2026.01.008 What is the main question of the paper? How does semaglutide (a GLP-1R agonist) produce chondroprotective effects in metabolic osteoarthritis (OA)? How did the anthor address the question? ■Step1 OA is a degenerative joint