Selected journal : Nature Universal transcriptomic hallmarks of mammalian ageing and mortality https://www.nature.com/articles/s41586-026-10542-3 What is the main question of the paper? Can universal transcriptomic signatures across mammalian species be used to quantify biological ageing, predict mortality risk, and reveal conserved mechanisms underlying ageing? How did the anthor address the question? ■Step1 1) Construction of a universal transcriptomic ageing model The auth

Selected journal : Cell Metabolism Iron-addicted colorectal cancers exploit heme–complex II axis to resist oxidative cell death https://www.cell.com/cell-metabolism/fulltext/S1550-4131(26)00185-3 What is the main question of the paper? What metabolic adaptations allow colorectal cancer(CRC) cells to survive under iron-rich environment which is lethal for normal intestinal epithelial cells or non-CRC cells, most cells. How did the anthor address the question? ■Step1 1. In vivo

Selected journal : Nature Sleep chart of biological ageing clocks in middle and late life https://www.nature.com/articles/s41586-026-10524-5 What is the main question of the paper? This study aims to answer a fundamental scientific question: What is the optimal daily sleep duration to maintain youthful organ health, and how do sleep extremes (overly short or long) drive systemic diseases, late-life depression, and all-cause mortality through distinct biological pathways? How

Selected journal : Cell Macrophage-mediated myelin recycling fuels brain cancer malignancy https://doi.org/10.1016/j.cell.2024.07.030 What is the main question of the paper? How do macrophages within glioblastomas promote tumor malignancy and recurrence? How did the anthor address the question? ■Step1 1. Identification of lipid-laden macrophages (LLMs) Using a genetically modified glioblastoma mouse model, as well as primary tumors and tumors that recurred after radiation the

Selected journal : Nature Ageing promotes metastasis via activation of the integrated stress response https://doi.org/10.1038/s41586-026-10216-0 What is the main question of the paper? How does physiological ageing alter tumor evolution in KRAS-mutant lung adenocarcinoma? How did the anthor address the question? ■Step1 They induced the same KRAS-mutant lung adenocarcinoma model in young and aged mice and compared the pattern of tumor progression. The authors induced lung aden

Selected journal : Cell Metabolism Brown fat protects against hepatic oxidative stress by remodeling the circulating metabolome https://www.sciencedirect.com/science/article/pii/S1550413126002469?via%3Dihub What is the main question of the paper? This study investigates the molecular mechanisms by which brown adipose tissue (BAT) communicates with the liver through circulating metabolites, with a particular fo cus on identifying BAT-derived signals that protect against hepati

Selected journal : Nature Metabolism Extracellular CD44 lactylation impairs CD8+ T cell function in KRAS-mutant colorectal cancer https://www.nature.com/articles/s42255-026-01482-3 What is the main question of the paper? What drives immune evasion in KRAS-mutant colorectal cancer? How did the anthor address the question? ■Step1 TRIP6 is high in KRAS-WT tumors, where it blocks the glycolytic enzyme ENO2 (via KDM1A/H3K9 methylation). More TRIP6 meant more CD8⁺ T cells in the tu

Selected journal : Nature Postprandial lipid metabolism durably enhances T cell immunity https://www.nature.com/articles/s41586-026-10432-8 What is the main question of the paper? While we know that long-term dietary habits affect immunity, does the acute nutritional state, such as fasting versus feeding within just a few hours after a single meal, alter the immune function and metabolic fate of T cells? If so, can these short-term changes be maintained over a long period? Ho

Selected journal : Cell A blood-brain barrier-like vascular gate limits immunotherapy efficacy in neuroendocrine cancers https://doi.org/10.1016/j.cell.2026.04.017 What is the main question of the paper? Why Does SCLC (Small Cell Lung Carcinoma) develop resistance to immune checkpoint inhibitors? How did the anthor address the question? ■Step1 1. Discovery of the BBB-like vascular gate (BVG) in SCLC. Using ICI-treated patient transcriptome datasets and SCLC patient tissue sam

Selected journal : Science Mitochondrial metabolism and signaling direct dendritic cell function in antitumor immunity https://pmc.ncbi.nlm.nih.gov/articles/PMC13109015/ What is the main question of the paper? How do intratumoral cDC1s maintain their antigen-presenting and CD8 T cell–activating function, and why is this function lost during tumor progression? How did the anthor address the question? ■Step1 They identified functionally distinct mitochondrial states in intratum