Selected journal : Nature Ageing promotes metastasis via activation of the integrated stress response https://doi.org/10.1038/s41586-026-10216-0 What is the main question of the paper? How does physiological ageing alter tumor evolution in KRAS-mutant lung adenocarcinoma? How did the anthor address the question? ■Step1 They induced the same KRAS-mutant lung adenocarcinoma model in young and aged mice and compared the pattern of tumor progression. The authors induced lung aden

Selected journal : Cell Metabolism Brown fat protects against hepatic oxidative stress by remodeling the circulating metabolome https://www.sciencedirect.com/science/article/pii/S1550413126002469?via%3Dihub What is the main question of the paper? This study investigates the molecular mechanisms by which brown adipose tissue (BAT) communicates with the liver through circulating metabolites, with a particular fo cus on identifying BAT-derived signals that protect against hepati

Selected journal : Nature Metabolism Extracellular CD44 lactylation impairs CD8+ T cell function in KRAS-mutant colorectal cancer https://www.nature.com/articles/s42255-026-01482-3 What is the main question of the paper? What drives immune evasion in KRAS-mutant colorectal cancer? How did the anthor address the question? ■Step1 TRIP6 is high in KRAS-WT tumors, where it blocks the glycolytic enzyme ENO2 (via KDM1A/H3K9 methylation). More TRIP6 meant more CD8⁺ T cells in the tu

Selected journal : Nature Postprandial lipid metabolism durably enhances T cell immunity https://www.nature.com/articles/s41586-026-10432-8 What is the main question of the paper? While we know that long-term dietary habits affect immunity, does the acute nutritional state, such as fasting versus feeding within just a few hours after a single meal, alter the immune function and metabolic fate of T cells? If so, can these short-term changes be maintained over a long period? Ho

Selected journal : Cell A blood-brain barrier-like vascular gate limits immunotherapy efficacy in neuroendocrine cancers https://doi.org/10.1016/j.cell.2026.04.017 What is the main question of the paper? Why Does SCLC (Small Cell Lung Carcinoma) develop resistance to immune checkpoint inhibitors? How did the anthor address the question? ■Step1 1. Discovery of the BBB-like vascular gate (BVG) in SCLC. Using ICI-treated patient transcriptome datasets and SCLC patient tissue sam

Selected journal : Science Mitochondrial metabolism and signaling direct dendritic cell function in antitumor immunity https://pmc.ncbi.nlm.nih.gov/articles/PMC13109015/ What is the main question of the paper? How do intratumoral cDC1s maintain their antigen-presenting and CD8 T cell–activating function, and why is this function lost during tumor progression? How did the anthor address the question? ■Step1 They identified functionally distinct mitochondrial states in intratum

Selected journal : cell Sulfur partitioning from cysteine controls T cell proliferation and effector function https://www.sciencedirect.com/science/article/pii/S0092867426002795 What is the main question of the paper? This study asks how intracellular partitioning of cysteine between glutathione (GSH) synthesis and NFS1-dependent iron–sulfur (Fe-S) cluster biogenesis regulates CD8⁺ T-cell proliferation, effector function, and anti-tumor immunity. How did the anthor address th

Selected journal : Cell metabolism Gut microbiota and metabolic control of immune checkpoint blockade in cancer https://www.cell.com/cell-metabolism/fulltext/S1550-4131(26)00156-7 What is the main question of the paper? What are the exact mechanisms by which the gut microbiota and their metabolites control the efficacy of immune checkpoint blockade (ICB) in cancer therapy? How did the anthor address the question? ■Step1 Clinical Correlation: Focused heavily on the detrimental

Selected journal : Science Mechanical load inhibits cancer growth in mouse and human hearts https://www.science.org/doi/epdf/10.1126/science.ads9412 What is the main question of the paper? The main question of this study is to investigate whether the high-intensity mechanical load generated by the continuous beating of the heart serves as a key mechanism for its natural resistance to cancer, including primary tumors and malignant metastases. Also it finds the molecular and ep

Selected journal : Cell Sensory neurons drive immune exclusion by stimulating a dense extracellular matrix in the breast cancer tumor microenvironment https://doi.org/10.1016/j.cell.2026.01.001 What is the main question of the paper? How do sensory neurons interact with the tumor microenvironment? How did the anthor address the question? ■Step1 They demonstrated that in TNBC tumor tissue, sensory neurons accelerate tumor progression by reducing immune cell infiltration and pr