Selected journal : Nature Metabolism Fat sensory cues in early life program central response to food and obesity https://www.nature.com/articles/s42255-025-01405-8 What is the main question of the paper? Can exposure to food odors during early life affect susceptibility to obesity later in life, independently of nutritional content? How did the anthor address the question? ■Step1 1) Separating food odors from nutritional content The authors fed mother mice a bacon-flavored di

Selected journal : Nature Histone readers MLLT1 and MLLT3 concentrate AID to confer locus specificity https://www.nature.com/articles/s41586-026-11087-1 What is the main question of the paper? How do the histone readers MLLT1 and MLLT3 confer locus specificity by concentrating and licensing activation-induced cytidine deaminase (AID) at immunoglobulin and selected off-target regions? How did the anthor address the question? ■Step1 Establishing MLLT1 and MLLT3 as essential AID

Selected journal : Science An in-body networking system for communication between wearable and implantable therapeutics https://doi.org/10.1126/science.adz5300 What is the main question of the paper? Inspired by the ionic signaling of the nervous system, can body tissue itself serve as the conductive medium for signal transmission—in place of power-hungry radio-frequency (RF) electronics—to build a syringe-injectable, near-zero-standby-power in-body network (SWANS) that gives

Selected journal : Nature Towards end-to-end automation of AI research https://www.nature.com/articles/s41586-026-10265-5#Abs1 What is the main question of the paper? The main question is whether an artificial intelligence system can autonomously navigate the entire scientific research life cycle, from conception to publication. While previous AI systems could only help with specific, narrow tasks—such as writing literature reviews, coding experiments, or predicting protein s

Selected journal : Cell Brain perivascular macrophages regulate endothelial cell function via a cMAF-dependent transcriptional program in mouse and human https://doi.org/10.1016/j.cell.2026.07.043 What is the main question of the paper? What transcriptional programs do perivascular macrophages (PVMs) use to maintain their cellular state and function and to regulate cerebral endothelial cells? How did the anthor address the question? ■Step1 1. Identification of cMAF as a trans

Selected journal : Cell Metabolism Remote limb ischemic conditioning alleviates steatohepatitis via extracellular vesicle-mediated muscle-liver crosstalk https://pubmed.ncbi.nlm.nih.gov/40118054/ What is the main question of the paper? Can remote limb ischemic conditioning improve MASH through muscle-to-liver communication, and what molecular mechanism mediates this effect? How did the anthor address the question? ■Step1 RIC improves MASH Chronic remote limb ischemic conditio

Selected journal : Nature Universal transcriptomic hallmarks of mammalian ageing and mortality https://www.nature.com/articles/s41586-026-10542-3 What is the main question of the paper? Can universal transcriptomic signatures across mammalian species be used to quantify biological ageing, predict mortality risk, and reveal conserved mechanisms underlying ageing? How did the anthor address the question? ■Step1 1) Construction of a universal transcriptomic ageing model The auth

Selected journal : Cell Metabolism Iron-addicted colorectal cancers exploit heme–complex II axis to resist oxidative cell death https://www.cell.com/cell-metabolism/fulltext/S1550-4131(26)00185-3 What is the main question of the paper? What metabolic adaptations allow colorectal cancer(CRC) cells to survive under iron-rich environment which is lethal for normal intestinal epithelial cells or non-CRC cells, most cells. How did the anthor address the question? ■Step1 1. In vivo

Selected journal : Nature Sleep chart of biological ageing clocks in middle and late life https://www.nature.com/articles/s41586-026-10524-5 What is the main question of the paper? This study aims to answer a fundamental scientific question: What is the optimal daily sleep duration to maintain youthful organ health, and how do sleep extremes (overly short or long) drive systemic diseases, late-life depression, and all-cause mortality through distinct biological pathways? How

Selected journal : Cell Macrophage-mediated myelin recycling fuels brain cancer malignancy https://doi.org/10.1016/j.cell.2024.07.030 What is the main question of the paper? How do macrophages within glioblastomas promote tumor malignancy and recurrence? How did the anthor address the question? ■Step1 1. Identification of lipid-laden macrophages (LLMs) Using a genetically modified glioblastoma mouse model, as well as primary tumors and tumors that recurred after radiation the