Department of Integrative Bioanalytics
Institute of Development, Aging and Cancer, Tohoku University
Integrative Bioanalytics
Understanding complex biological interactions using multi-omics analysis
Tohoku University, Institute of Development, Aging and Cancer / Graduate School of Medicine and Graduate School of Life Sciences
Kyoto University Institute of Medical Biology
IDAC, Tohoku University / LiMe, Kyoto University
About Us
Our laboratory integrates experimental design, large-scale data generation, and computational analysis to uncover biological mechanisms. We also develop analytical frameworks that maximize the value of large-scale biological datasets.
Decoding biological systems through large-scale data analysis
Integrating experiments, multi-omics, and computation to uncover the principles of biological regulation.
Decoding biological systems through large-scale data analysis
Recent advances in life science and medical technologies have enabled us to measure biological information at unprecedented scale and resolution.
We can now analyze whole genomes, gene expression in individual cells, metabolite profiles, physiological signals, and rich clinical or personal background information. However, generating large-scale data does not automatically lead to biological understanding.
A major challenge is to interpret these diverse layers of information and connect them across biological scales—from molecules and cells to organs, individuals, and behavior.
Our laboratory develops integrative bioanalytical approaches to address this challenge.
Research Overview
Our research spans multiple biological systems, from molecular mechanisms to human physiology. Across all projects, we integrate experimental biology, multi-omics, physiology, and computational analysis to understand biological responses across multiple scales.
—Cancer-induced host dysfunction—
Although tremendous progress has been made in understanding cancer itself, the mechanisms by which cancer disrupts host physiology remain poorly understood. We investigate cancer-induced host dysfunction by integrating genetics, multi-omics, and multi-organ analyses.
—Enhancer-mediated regulation of physiology, immunity, and aging—
We investigate how enhancers regulate biological responses to environmental and physiological perturbations. By studying gene regulation in contexts such as circadian rhythms, immunity, and aging, we aim to understand how non-coding genomic regions shape organismal homeostasis.
—Understanding human responses to robots, avatars, and digital technologies—
Digital technologies, including avatars, wearable devices, and human–AI interactions, are becoming part of everyday life. We investigate how these technologies influence human physiology and behavior through multidimensional bioresponse analysis.
If you are interested in this research or our approach, please feel free to contact us.
Latest News
Recruitment open!
[We are currently recruiting for an Assistant Professor position.]
We welcome applications from individuals who wish to deepen their independent and original research.
Our laboratory provides the optimal equipment and environment to accelerate your research.
Let's advance our research together.
Inquiry
Seiryo-machi 4-1, Aoba-ku, Sendai, Miyagi, Japan / Shogoin-kawaharacho 53, Sakyo-ku, Kyoto-shi, Kyoto, Japan